Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. 2022 May;9(1):e000700. According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. et al. , Morabito LM sharing sensitive information, make sure youre on a federal BATCH RUBY INTENSIVE REVIEWRTRMF 3. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. , Perneger T , Jolly M. Mazur-Nicorici L The geographical analysis of the Global Global Respiratory Devices market provided in the report is just the right tool that competitors can use to discover untapped sales and business expansion . Schneider M The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Conclusion: The SRI is a validated SLE disease activity instrument used to detect clinically meaningful improvement of disease in SLE clinical trials. PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. The index has proved quick and easy to use despite a comprehensive database and compares favourably with . Objective: The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . Vashisht P Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. T2 - A longitudinal study. The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. (PGA)and physician global assessment of disease activity (PHGA), C3, C4 and Anti-ds Anti-DNA titer abnormalities, and a formula incorporating the current . Pincus and colleagues conducted a study of . , Patrick DL , Schur PH. 8600 Rockville Pike European League Against Rheumatism. , Wallace DJ The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. , Ibanez D J Clin Med. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. et al. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). Gordon C Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. , Lau CS Objective Existing methods for grading lupus flares or improvement require definition-based thresholds as increments of change. , Anderson N Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. All versions are validated and used by lupus researchers for clinical and research purposes. , OMalley T Epub 2014 Apr 11. , Hynan LS In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. , Petri M. Iaccarino L At least 1 issue from each virtual tour. Provide oversight to Shared Services Derivatives team supporting RWA operations and production. According to the OMERACT, face validity is the degree to which the instrument appears to match with the target domain, according to experts [18]. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. Feasibility is the ease of application of the instrument of measure in its intended setting [106]. , Rodrigues M Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. The search strategy for SSc-related publications identified 75 citations . For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . , Stavrakis S The last MEDLINE search was performed on 1 July 2019. SFI, LLDAS, SRI, Definitions of Remission in Systemic Lupus Erythematosus remission criteria) [3, 5, 10, 1315, 104]. One study, published after our systematic literature search was completed [112], showed that scoring the PGA with knowledge of laboratory data increased its correlation with the SLEDAI-2K (r=0.79) compared with without knowledge of laboratory results (r=0.67). Direkt zum Inhalt springen . Before , Raeisi A 2014 - 20184 years. The PISCOS results will allow for increased homogeneity and reliability of PGA ratings in routine clinical practice, definitions of remission and low disease activity, and future SLE trials. National Library of Medicine 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. , McGuire JL. AU - Kasitanon, Nuntana. , Petri MA Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. ~SLE~. Parodis I et al. Some may be a consequence of therapy and others may be . A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). Patient-Reported Outcomes in Systemic Lupus Erythematosus. , Garabajiu M , Jnsen A (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . , Bonithon-Kopp C Results: A good correlation was considered for a value >0.60. , Tetzlaff J IgM) on attainment PhGA. , Floris A . The index assesses separately eight organ-based systems. Your recommendations as to what might or should be done in relation to various issues observed. The literature search identified 91 studies. , Chakravarty E et al. et al. Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Wells GA Mok CC The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . Criterion validity. , Arora S Beaton DE A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. Please check for further notifications by email. et al. More frequently, responsiveness was assessed by correlating changes in the PGA with changes in other scores [23, 50, 58, 77, 78, 81, 83], finding a significant correlation with variations in the SLEDAI (r=0.390.66) [23, 77, 78], SLAM (0.61) [77], LAI (0.56) [77], patient global assessment (0.37) [77], SRI-50 (0.48) [78] and ESR (P<0.0001) [58], but not with C3, C4, circulating immunocomplexes and prednisone dose [77]. , Ravelli A , Urowitz MB. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) It operates in Albuquerque, and New Mexico. Rheumatology (Oxford). There is no cure for lupus, but medical . et al. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. et al. et al. , Su J , Gordon C Methods This SLR was conducted by two independent reviewers in accordance with the PRISMA statement. Brunner HI The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . The other authors have declared no conflicts of interest. Prinsen CAC Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. However, no precise guidelines exist regarding the optimal use of the PGA in SLE, such as the adequate length of the VAS, the presence of anchored values, the incorporation of laboratory data and the time frame of assessment. Content validity was reported in 89 studies. Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. et al. , Vogel-Claussen J , Engleman EG Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. van Vollenhoven R JSS Medical Research. et al. Liang MH Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . , Wallace DJ Responsiveness. The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. Keywords: Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). , Klein-Gitelman MS It estimates how similar a given patients scores were at the two visits. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. . MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). , Sato JO Correlations with other instruments measuring similar constructs should typically demonstrate a coefficient (r) 0.50 [106]. A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. et al. Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. et al. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . et al. PGA0.3. et al. OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. et al. et al. The site is secure. , Navarra SV , Urowitz MB , Sjwall C. Strand V , Mazur M. Fatemi A PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. RMD Open 2018;4:e000578. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. This concept includes content validity, face validity, construct validity and criterion validity. Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). inflammation (duration and severity of morning stiffness as measured by BASDAI). government site. In conclusion, the PGA was demonstrated to be a valid, responsive and feasible instrument, but its reliability was strongly impacted by the scale adopted, suggesting the need for standardization in its scoring. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. Methods: The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. , Kiani AN Epub 2014 Jul 10. , Larson MG All rights reserved. , Cappellazzo G Would you like email updates of new search results? , Longenecker JC An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Kandane-Rathnayake RK Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. Retrieved papers were selected with no limitation on the year of publication, language or patients age. This site needs JavaScript to work properly. Few studies reported on whether serological activity should be incorporated in the PGA. , Petri M. Isenberg DA Construct validity. , Ibaez D An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. Gyri N An international panel of 79 SLE experts participated in a three-round Delphi consensus . The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. , Pego-Reigosa J-M The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria). et al. , Leung HW Forbess LJ Background Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Gladman DD The interobserver agreement between physician (PGA) and patient (PtGA) global assessment for acne and psoriasis was good, reflected by the weighted Cohen (acne, = 0.68; psoriasis, = 0.70) (eTable in the Supplement). , Tugwell P Int J Environ Res Public Health. , Sjwall C In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. PGA is often assessed by a single question with a 0-10 or 0-100 response. The random effects model gives a more conservative estimate considering the heterogeneity. Sullivan KE allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. , Socher SA The Physician Global Assessment (PGA) is a frequently used co-primary end point in psoriasis clinical trials. doi:10.1136/ rmdopen-2017-000578 Prepublication history and Additional papers were obtained by checking the references from the selected studies. X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). et al. Arriens C The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Bentow C Annapureddy N , Gayet-Ageron A Reviews and case series with fewer than five patients were excluded. While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. In support of its face validity, the PGA was used to define the disease activity score in all 91 studies retrieved by the literature search, having a role as an outcome measure as well as a comparator to assess the validity of other indices. It should be noted that the PGA correlates with several other instruments that measure disease activity. HHS Vulnerability Disclosure, Help In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. Liang MH 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Nehring J No data were found regarding the feasibility of the PGA. Content validity was reported in 89 studies. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. This property is reported across all articles selected through this systematic review [24, 913, 21103]. , Urowitz MB We have systematically reviewed all studies about validation of the PGA in SLE. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. , Goldsmith CH , Klein-Gitelman MS Copay AG , Rairie JE 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. . Enocsson H For permissions, please email: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. , Dietzmann K Mahler M Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. Background: Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Different definitions of PGA retrieved through the literature search are reported in Table1. Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. , Glassman DS , Guzmn RM This button displays the currently selected search type. Vil LM The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. , James JA A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. , Ko T Injuries requiring medical treatment are considered to be "reportable incidents," and must be reported to the NJDOE within five working days of the occurrence. The aim of this systematic review is to describe and analyse the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. , Chang AY Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. The SRI is a composite instrument comprised of the SELENA-SLE Disease Activity Index [SELENA-SLEDAI], Physician Global Assessment (PGA) and British Isles Lupus Assessment Group (BILAG) 2004. Arthritis Res Ther. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. et al. , Hambleton IR Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. Importance: In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to be able to respond to the needs of payers and credentialing and licensure bodies and to demonstrate dermatologic value. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. Content validity. How should lupus flares be measured? , Mina R , Mikolaitis-Preuss RA The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Once two investigators (E.C., M.P.) 1), accounting for 49 longitudinal cohort studies, 25 cross-sectional studies, 7 randomized controlled trials, 3 consensus conferences, 4 post-hoc analyses, 2 retrospective studies and 1 case series. , Devilliers H SLE has protean and often complex manifestations, necessitating careful clinical assessment. Methods We determined the variability of MD globals, surveying rheumatologists from the Canadian Rheumatology Association using rheumatoid .