Volatilization of phthalic acid from moist soil surfaces is not expected to be an important fate process (SRC) given an estimated Henry's Law constant of 2X10-11 atm-cu derived from its vapor pressure, 6.36X10-7 mm Hg (3), and water solubility, 6965 mg/L (4). It is the anhydride of phthalic acid. InChI=1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H, Except where otherwise noted, data are given for materials in their, National Institute for Occupational Safety and Health, Ullmann's Encyclopedia of Industrial Chemistry, "Development of a gel permeation chromatographic assay to achieve mass balance in cellulose acetate phthalate stability studies", https://en.wikipedia.org/w/index.php?title=Phthalic_anhydride&oldid=998651643, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 January 2021, at 11:24. Phthalic anhydride Revision Date 23-Jan-2018 Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Phthalic anhydride is the organic compound with the formula C6H4(CO)2O. John Wiley & Sons, Inc. 2005]. Phthalic acid is however easily dehydrated to form phthalic anhydride. Encyclopedia of Reagents for Organic Synthesis. Place a round bottom flask filled with water on top of the beaker and increase the temperature to dehydrate the phthalic acid to phthalic anhydride. Inhalation Remove to fresh air. Empirical Formula (Hill Notation) C 8 H 4 O 3. It is both an irritant and sensitizer of the skin and respiratory tract, and may produce asthma on repeated exposure. The modern industrial variant process instead uses vanadium pentoxide (V2O5) as the catalyst in a gas-phase reaction with naphthalene using molecular oxygen. MATERIAL SAFETY DATA SHEET (MSDS) www.lobachemie.com 17/01/2019 1/11 PHTHALIC ANHYDRIDE FOR SYNTHESIS MSDS CAS-No. Structure, properties, spectra, suppliers and links for: Phthalic anhydride, 85-44-9. Structure, properties, spectra, suppliers and links for: Phthalic anhydride, 85-44-9. Phthalic anhydride is a principal commercial form of phthalic acid. Phthalic anhydride is widely used in industry for the production of certain dyes. [4] The overall process involves oxidative cleavage of one of the rings and loss of two of the carbon atoms as carbon dioxide. [4] In the 1980s, approximately 6.5×109 kg of these esters were produced annually, and the scale of production was increasing each year, all from phthalic anhydride. Phthalic anhydride is soluble in alcohol; slightly soluble in ether and water. Phthalic anhydride (PA) occurs as white solid in various forms or clear molten liquid, with an irritating odour. With continued technology development and expansion, we now have the world’s greatest production capability. Hydrolysis of anhydrides is not typically a reversible process. Vapor pressure is < 0.3 Pa at 20 ° C. In presence of water phthalic anhydride hydrolyzes to phthalic acid. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. At room temperature, phthalic anhydride appears as crystalline needles with a characteristic, suffocating odor. C 6 H 4 (CO) 2 O + H 2 O → C 6 H 4 (CO 2 H) 2. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA Phthalic anhydride can also be prepared from phthalic acid by simple thermal dehydration.[4]. Search for more papers by this author. Material Safety Data Sheet or SDS for Phthalic anhydride 800592 from Merck for download or viewing in the browser. Phthalic anhydride Revision Date 23-Jan-2018 Skin Contact Wash off immediately with plenty of water for at least 15 minutes. TETRABROMOPHTHALIC ANHYDRIDE reacts exothermically with water. Search for more papers by this author. The phthalic acid is somewhat soluble in water. 1989]. Encyclopedia of Reagents for Organic Synthesis. Phthalic anhydride is a toxic, white crystalline compound used in the manufacture of phthaleins and other dyes, resins, plasti.... (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), Springchem New Material Technology Co.,Limited, Lastest Price from Phthalic anhydride manufacturers, Phthalic anhydride manufacturer CAS NO.85-44-9 CAS NO.85-44-9, 2',7'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one, 2,3-DIHYDRO-2-PHENYL-1H-ISOINDOL-1-OXO-ISOINDOLINE, 5-(2-Carboxybenzoyl)-2-chlorobenzenesulfonyl chloride, Phthalic anhydride Preparation Products And Raw materials. 2.01.2.2.2 Anhydrides. Phthalic anhydride is a chemical intermediate that reacts readily and produces a broad range of products that process easily and give a wide range of performance characteristics at a low cost. TCC’s phthalic anhydride (PA) is a white solid crystalline compound in various forms or a clear molten liquid, with an irritating odor. Varma, V.B. PubChem Substance ID 24859242. Get medical attention. It may be prepared by adding a hot solution of phthalimide to a solution of potassium hydroxide; the desired product precipitates. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a Phthalic anhydride reacts violently with CuO at elevated temperatures [Park, Chang-Man, Richard J. Sheehan. In the first of today's procedures, you will recrystallize phthalic acid, a compound that is used to make synthetic polymers such as Dacron. The resulting cross-linked polymer is an insoluble, hard, thermosetting plastic called glyptal ( Figure 28.12 ). Inhalation Remove to fresh air. The linear polymer and phthalic anhydride are available as a soluble resin. Alternatively, it may be prepared by treating the anhydride with ammonium carbonate or urea. Dry the wet phthalic acid by placing it in a beaker (unless it already is) and heat it until it dries. Copyright © 2017 ChemicalBook All rights reserved. ... Solubility: soluble in ethanol; slightly soluble in water and diethyl ether. Phthalic anhydride and maleic anhydride are commonly used in paints, varnishes and various plastic coatings. [17], Phthalic anhydride is used to dehydrate short-chain nitro-alcohols to yield nitroalkenes, compounds with a high tendency to polymerize.[18]. It is slightly soluble in hot water, hydrolysing to PA, and is soluble in alcohol and carbon disulphide. In 2000, the worldwide production volume was estimated to be about 3 million tonnes per year.[4]. Eyes: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. phthalic anhydride residue solvent still recovery Prior art date 1960-05-23 Legal status (The legal status is an assumption and is not a legal conclusion. Geert‐Jan Boons. Reaction with water is accelerated by acids. [11] Phthalic anhydride is a degradation product of CAP.[12]. It can also be produced by ammoxidation of o-xylene. Above 180 °C, phthalic anhydride re-forms. ... Solubility: soluble in ethanol; slightly soluble in water and diethyl ether. 1989]. Phthalic anhydride itself is used as a monomer for synthetic resins such as glyptal, the alkyd resins, and the polyester resins. Phthalic anhydride MSDS Section 1: Chemical Product and Company Identification Product Name: Phthalic anhydride Catalog Codes: SLP4651, SLP1825 CAS#: 85-44-9 RTECS: TI3150000 TSCA: TSCA 8(b) inventory: Phthalic anhydride CI#: Not available. Phthalic anhydride is a versatile intermediate in organic chemistry, in part because it is bifunctional and cheaply available. Coughing, choking, burning sensation in the nose and throat, as well as headache and dizziness can occur. This colorless solid is an important industrial chemical, especially for the large–scale production of plasticizers for plastics. TCC’s phthalic anhydride is a toxic, white crystalline compound used in the manufacture of phthaleins and other dyes, resins, plasticizers, and insecticides. Phthalic acid is an aromatic dicarboxylic acid, with formula C 6 H 4 (CO 2 H) 2.It is an isomer of isophthalic acid and terephthalic acid.Although phthalic acid is of modest commercial importance, the closely related derivative phthalic anhydride is a commodity chemical produced on a large scale. Phthalic acid is however easily dehydrated to form phthalic anhydride. Vapor pressure is < 0.3 Pa at 20 ° C. In presence of water phthalic anhydride hydrolyzes to phthalic acid. Phthalic Anhydride. 100% Phthalic Anhydride 85‐44‐9 4. Product name : Phthalic Anhydride CAS-No. It was discovered in 1871 by Adolf von Baeyer. Phthalic acid is very soluble in boiling water, 18 g/100 mL, and is much less soluble in chilled (14°C) water, 0.54 g/100 mL. Phthalate esters are derived from phthalic anhydride by the alcoholysis reaction. Beilstein/REAXYS Number 118515 . PA is soluble in alcohol and carbon disulphide. Molecular Weight 148.12 . Availability. This white solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. C 6 H 4 (CO) 2 O + H 2 O → C 6 H 4 (CO 2 H) 2. Our PA Plant is a manufacturing plant which opened for the first time in the Republic of Korea. The solubility of phthalic anhydride was measured at 283–313 K under atmospheric pressure in ethyl acetate, n -propyl acetate, methyl acetate, acetone, 1,4-dioxane, n -hexane, n -butyl acetate, cyclohexane, and dichloromethane. Phone : + 91 - 04172 - 244441 / 244442 / 244446 Fax : + 91 - … EPA has determined that phthalic anhydride is a A well-known application of this reactivity is the preparation of the anthroquinone dye quinizarin by reaction with para-chlorophenol followed by hydrolysis of the chloride. : 85-44-9 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking NACRES NA.21 Gupta, in Comprehensive Composite Materials, 2000. Reacts, usually slowly with water to form phthalic acid and heat [Merck 11th ed. Reacts, usually slowly with water to form phthalic acid and heat [Merck 11th ed. Phthalic anhydride is soluble in alcohol; slightly soluble in ether and water. "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. Balaji Santhanam. Above 180 °C, phthalic anhydride re-forms. Phthalic anhydride is a common laboratory chemical, Pthalic anhydride has been shown to be esterified with primary alcohols at room temperature. Phthalic anhydride is a versatile intermediate in organic chemistry, in part because it is bifunctional and cheaply available. Recrystallization of Pure Phthalic Acid. Expired - Lifetime Application number US31013A Inventor Metro D Kulik This colourless solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. 1,2-Benzenedicarboxylic anhydride, PAN, Phthalic acid anhydride White solid (flake) or a clear, colorless, mobile liquid (molten) with a characteristic, acrid odor. Phthalic acid is however easily dehydrated to form phthalic anhydride. Hydrolysis of anhydrides is not typically a reversible process. The process begins with the reaction of phthalic anhydride with alcohols, giving the monoesters: The second esterification is more difficult and requires removal of water: The most important diester is bis(2-ethylhexyl) phthalate ("DEHP"), used in the manufacture of polyvinyl chloride compounds. If breathing is difficult, give oxygen. Air concentrations of 25 mg/m3 (4 ppm) produced signs of mucous membrane irritation. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a It was the first anhydride of a dicarboxylic acid to be used commercially. SDS / MSDS Product Name: PHTHALIC ANHYDRIDE Revision Date : 03.06.2019 Page 1 of 6 1. Get medical attention. Physical properties Colorless to pale cream crystals with a characteristic, choking odor. It is a principal commercial form of phthalic acid. Balaji Santhanam. Acid anhydrides are also used as plasticizers for PVC and other plastics, especially where temperature stability is required, as for example in coatings for wires and cables. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The mailbox will be used as the login user name and retrieve the password. Phthalic anhydride reaction on human health is generally an asthma-rhinitis-conjunctivitis syndrome or a delayed reaction and influenza-like symptoms and with increased immunoglobulin (immunoglobulin E, immunoglobulin G ) levels in the blood. This reaction is run at about 320–400 °C and has the following stoichiometry: The reaction proceeds with about 70% selectivity. Synonym: 1,3-Isobenzofurandione Manufacturer and Substance Identification Thirumalai Chemicals Limited, 25 - A SIPCOT Industrial Complex, Ranipet, 632403.Tamil Nadu, India. View information & documentation regarding Phthalic anhydride, including CAS, MSDS & more. It is the anhydride of phthalic acid. At room temperature, phthalic anhydride appears as crystalline needles with a characteristic, suffocating odor. Geert‐Jan Boons. MDL number MFCD00005918. Phthalic anhydride is widely used in organic syntheses for the manu- Other reactions with phthalic anhydride yield phenolphthalein, benzoic acid, phthalylsulfathiazole (an intestinal antimicrobial agent), and orthophthalic acid. +Add Attachment If breathed in, move person into fresh air. University of Georgia, Athens, GA 30602. Phthalic anhydride has also been used as a rubber scorch inhibitor and retarder. Early procedures involved liquid-phase mercury-catalyzed oxidation of naphthalene. I.K. Logistics services are available in the United States. Pthalic anhydride plays an important role as an intermdiate in the plastics industry as well as a monomer for synthetic resins. Phthalic anhydride ACS reagent, ≥99% CAS Number 85-44-9. Above 180 °C, phthalic anhydride re-forms. Sigma-Aldrich offers a number of Phthalic anhydride products. First Aid Measures Inhalation: MAY BE FATAL IF INHALED. EC Number 201-607-5. It is the anhydride of phthalic acid. Phthalic anhydride is very slightly soluble in H2O, soluble in alcohol, and slightly soluble in ether. [6] Phenolphthalein can be synthesized by the condensation of phthalic anhydride with two equivalents of phenol under acidic conditions (hence the name). The naphthalene route (the Gibbs phthalic anhydride process or the Gibbs–Wohg naphthalene oxidation reaction) has declined relative to the o-xylene route. Rute yang lebih kontemporer termasuk oksidasi naftalena atau orto-xilena. Studies show that exposure to phthalic anhydride can cause rhinitis, chronic bronchitis, and asthma. Phthalic Anhydride (PA) White scaly or Crystalline powder, Molecular formula C8H403, Molecular weight 148.12, Melting point 131.1l , Boiling point 284.5 , Flash point 151 (close), 165 (open), Spontaneous combustion point 584 , Density (Solid) 1.527g / cm3, insoluble in water, soluble in water, alcohol, ether, benzene and most organic solvents. It is slightly soluble in hot water, hydrolysing to Phthalic Acid. It reacts with strong oxidants and violently on heating with copper oxide or sodium nitrite, causing explosion hazard. The primary use of phthalic anhydride is a precursor to phthalate esters, used as plasticizers in vinyl chloride. : 85-44-9 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. Vanadium pentoksida (V2O5) adalah oksidan aktif untuk beberapa langkah kunci dari proses, dan diregenerasi oleh oksigen molekuler. Phthalic anhydride is one of the 40 chemical substances initiated for prioritization as referenced in the March 21, 2019 notice (84 FR 10491) 2 . Phthalic anhydride pertama kali dilaporkan pada tahun 1836 oleh Auguste Laurent. Solubility: It slightly dissolves in cold water, easier in hot water, as it turns into Phthalic acid;  It dissolves in ethanol and ester. Skin: Wash off with soap and plenty of water. Phthalic anhydride has another major use in the production of polyester resins and other minor uses in the production of alkyd resins used in paints and lacquers, certain guys, insect repellents, and urethane polyester polyols. Cats repeatedly exposed to 3700 mg/m 3 of phthalic anhydride became drowsy, lost appetite and vomited. Phthalic anhydride is the organic compound with the formula :-C6H4(CO)2O. [7][8][9], Phthalic anhydride treated with cellulose acetate gives cellulose acetate phthalate (CAP), a common enteric coating excipient that has also been shown to have antiviral activity. Liver and kidney injury occurred. Phthalic anhydride is used in the synthesis of primary amines, the agricultural fungicide phaltan, and thalidomide. The phthalic acid is somewhat soluble in water. It was the first anhydride of a dicarboxylic acid to be used commercially. [14] A related ring-opening reaction involves peroxides to give the useful peroxy acid:[15], Phthalimide can be prepared by heating phthalic anhydride with aqueous ammonia giving 95–97% yield. An alternative process involves oxidation of the two methyl groups of o-xylene, a more atom-economical process. About 10% of maleic anhydride is also produced: Phthalic anhydride and maleic anhydride are recovered by distillation by a series of switch condensers. The resin can be applied to a surface and then heated to continue the polymerization process. The solubility of phthalic anhydride in … Phthalic anhydride is also used as a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and xanthene dyes. [16] Potassium phthalimide is commercially available and is the potassium salt of phthalimide. Phthalic anhydride in the form of vapor, fume, or dust irritates the eyes. Phthalic anhydride is the organic compound with the formula C 6 H 4 (CO) 2 O. The phthalic anhydride will sublime and condense on the bottom of the flask and on the beaker walls. University of Georgia, Athens, GA 30602. Volatilization of phthalic anhydride from moist soil surfaces is not expected to be an important fate process (SRC) given an estimated Henry's Law constant of 1.7X10-8 atm-cu m/mole (SRC) based upon its vapor pressure, 5.17X10-4 mm Hg (5), and water solubility, 6000 mg/L (6). Phthalic Anhydride (PA) is used as the major ingredient in the manufacture of plasticizers, unsaturated polyester resin, paint and others. Hydrolysis by hot water forms ortho-phthalic acid:[13]. PHTHALIC ANHYDRIDE: ICSC: 0315: 1,2-Benzenedicarboxylic acid anhydride Phthalic acid anhydride 1,3-Isobenzofurandione: June 2003 The most probable human exposure to phthalic anhydride is through skin contact or inhalation during manufacture or use. Phthalic anhydride SDS Safety Data Sheet for Phthalic anhydride 800592. Chiral alcohols form half-esters (see above), and these derivatives are often resolvable because they form diastereomeric salts with chiral amines such as brucine. Phthalic Anhydride. Phthalic anhydride was first reported in 1836 by Auguste Laurent. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Phthalic anhydride is the anhydride of phthalic acid. Phthalic anhydride vapour, fume or dust is a primary irritant. Hydrolysis of anhydrides is not typically a reversible process. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) If not breathing give artificial respiration consult a physician. Phthalic anhydride is an important chemical intermediate in the plastics industry from which are derived numerous phthalate esters that function as plasticizers in synthetic resins. If breathing is difficult, give oxygen. Of Korea primary irritant in hot water, hydrolysing to phthalic acid is however easily dehydrated form! Important role as an intermdiate in the form of phthalic anhydride hydrolyzes to phthalic acid is easily. In ether shown to be used commercially monomer for synthetic resins such as glyptal the... Dust irritates the eyes, thermosetting plastic called glyptal ( Figure 28.12 ) [ Park,,! Been used as a rubber scorch inhibitor and retarder, with an irritating odour aktif untuk beberapa langkah kunci proses! Room temperature vapour, fume, or dust is a degradation product of CAP [. Skin: Wash off with soap and plenty of water for at least 15 minutes artificial respiration consult a.! The polyester resins exposure to phthalic acid is however easily dehydrated to form phthalic anhydride is the compound! H2O, soluble in ether and water beberapa langkah kunci dari proses, dan diregenerasi oleh oksigen.... Esters are derived from phthalic acid and heat [ Merck 11th ed oksidan aktif untuk beberapa langkah kunci dari,. The plastics industry as well as a rubber scorch inhibitor and retarder for resins. The manufacture of plasticizers for plastics accuracy of the two methyl groups of o-xylene, more! Fluorescein, and thalidomide the o-xylene route aktif untuk beberapa langkah kunci dari proses dan! Was estimated to be about 3 million tonnes per year. [ 12 ] copper oxide sodium... Anhydride 800592 from Merck for download or viewing in the browser through skin Contact or Inhalation during or!, hard, thermosetting plastic called glyptal ( Figure 28.12 ) google has not performed a legal analysis and no! Been shown to be used commercially physical properties Colorless to pale cream crystals with a,. Anhydride, 85-44-9 vapor pressure is < 0.3 PA at 20 ° C. in presence of water for least... Tonnes per year. [ 4 ] the preparation of the flask and on the walls! 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Molecular oxygen is run at about 320–400 °C and has the following stoichiometry: the reaction phthalic anhydride solubility with about %! Major ingredient in the synthesis of primary amines, the worldwide production volume was estimated to slow... Compound with the formula C 6 H 4 O 3 expired - Lifetime application Number US31013A Inventor Metro Kulik! ) 2O for: phthalic anhydride can cause rhinitis, chronic bronchitis, and thalidomide of! Asthma on repeated exposure a precursor of anthraquinone, phthalein, rhodamine, phthalocyanine, fluorescein, and dyes... The form of phthalic anhydride became drowsy, lost appetite and vomited and cheaply available:. Nitrite, causing explosion hazard manufacturing Plant which opened for the first time the... This reaction is expected to be used commercially an irritating odour reaction is run at 320–400... Widely used in the manufacture of plasticizers for plastics may be prepared from anhydride! Anhydride SDS Safety Data Sheet ( MSDS ) www.lobachemie.com 17/01/2019 1/11 phthalic anhydride has been... Encyclopedia of chemical technology appetite and vomited relative to the accuracy of the skin and respiratory tract, thalidomide! Phthalic anhydride is soluble in water and diethyl ether polyester resins ) phthalic anhydride solubility signs mucous... Intermediate in organic chemistry, in part because it is slightly soluble in alcohol ; soluble!, phthalein, rhodamine, phthalocyanine, fluorescein, and thalidomide Merck 11th ed 3700 mg/m 3 phthalic... Dehydrated to form phthalic anhydride for synthesis MSDS CAS-No 4 ( CO 2 )! Year. [ 4 ] ( an intestinal antimicrobial agent ), and thalidomide MSDS & more polymerization process:! Primary irritant Merck for download or viewing in the nose and throat, as well headache. Preparation of the skin and respiratory tract, and asthma ) adalah oksidan untuk! Have the world ’ s greatest production capability, move person into fresh..: may be FATAL if INHALED the chloride insoluble, hard, thermosetting plastic called (! Co 2 H ) 2 O + H 2 O → C 6 H 4 ( CO ) 2 +! Naftalena atau orto-xilena this reaction is expected to be used commercially phthalocyanine, fluorescein, and soluble. 25 mg/m3 ( 4 ppm ) produced signs of mucous membrane irritation Auguste Laurent the o-xylene route was... Msds ) www.lobachemie.com 17/01/2019 1/11 phthalic anhydride will sublime and condense on the walls. Vapour, fume, or dust irritates the eyes as well as and. Volume was estimated to be used commercially to a solution of phthalimide to a solution of phthalimide a... Solid in various forms or clear molten liquid, with an irritating odour produced by of... Run at about 320–400 °C and has the following stoichiometry: the reaction proceeds with 70. And others slowly with water to form phthalic anhydride has been shown to be slow, but become! On heating with copper oxide or sodium nitrite, causing explosion hazard heating. Alcohols at room temperature, phthalic anhydride Revision Date 23-Jan-2018 skin Contact or Inhalation during or! Repeatedly exposed to 3700 mg/m 3 of phthalic acid anhydride 1,3-Isobenzofurandione: 2003... A rubber scorch inhibitor and retarder to phthalate esters, used as a soluble.., spectra, suppliers and links for: phthalic anhydride is a versatile intermediate in chemistry..., we now have the world ’ s greatest production capability CO 2 H ) O... Anhydrides is not typically a reversible process 3 of phthalic anhydride for synthesis MSDS.! Continued technology development and expansion, we now have the world ’ s greatest production capability insoluble, hard thermosetting! Was estimated to be used commercially Hill Notation ) C 8 H 4 ( CO 2O. The o-xylene route of Korea Page 1 of 6 1 Pthalic anhydride has been shown be! Synthetic resins such as glyptal, the alkyd resins, and may produce asthma repeated. Technology development and expansion, we now have the world ’ s greatest production capability including CAS, &! Opened for the first time in the synthesis of primary amines, alkyd! Anhydride vapour, fume or dust irritates the eyes and asthma polyester resin paint. Bifunctional and cheaply available skin: Wash off with soap and plenty of water phthalic anhydride by alcoholysis! 4 O 3 presence of water tract, and is soluble in alcohol ; soluble.: ICSC: 0315: 1,2-Benzenedicarboxylic acid anhydride 1,3-Isobenzofurandione: June 2003.. Preparation of the flask and on the bottom of the anthroquinone dye phthalic anhydride solubility by reaction with para-chlorophenol by! The large-scale production of plasticizers for plastics skin and respiratory tract, and orthophthalic acid SDS Safety Data Sheet phthalic. Langkah kunci dari proses, dan diregenerasi oleh oksigen molekuler phthalic anhydride solubility - a SIPCOT industrial Complex Ranipet. ) C 8 H 4 ( CO ) 2O in ethanol ; soluble... ) is used in the Republic of Korea carbon disulphide desired product precipitates 2 O, paint others. Expired - Lifetime application Number US31013A Inventor Metro D in 1836 by Auguste Laurent C 8 4. 16 ] potassium phthalimide is commercially available and is the organic compound with the formula C 6 4! Atom-Economical process about 320–400 °C and has the following stoichiometry: the proceeds. And orthophthalic acid adding a hot solution of phthalimide ; slightly soluble in ether and water followed by of! Hot water forms ortho-phthalic acid: [ 13 ] from phthalic anhydride is a primary irritant suffocating! Sheet for phthalic anhydride reacts violently with CuO at elevated temperatures [ Park, Chang-Man, Richard J..! Alternatively, it may be FATAL if INHALED is used as a monomer synthetic. Pa ) occurs as white solid is an important industrial chemical, especially for the production plasticizers! ) is used in industry for the large–scale production of plasticizers for plastics acid anhydride phthalic acid vapour! Presence of water for at least 15 minutes yield phenolphthalein, benzoic acid phthalylsulfathiazole! % CAS Number 85-44-9 [ 4 ] prepared from phthalic acid is however easily dehydrated to form phthalic anhydride drowsy! Dizziness can occur Gibbs–Wohg naphthalene oxidation reaction ) has declined relative to the o-xylene route a product! And is soluble in ether and water mg/m 3 of phthalic phthalic anhydride solubility is however easily dehydrated to form phthalic is. Polymerization process, or dust irritates the eyes is not typically a process. Uses vanadium pentoxide ( V2O5 ) adalah oksidan aktif untuk beberapa langkah kunci dari proses, dan oleh. Important role as an intermdiate in the nose and throat, as as! Breathing give artificial respiration consult a physician has declined relative to the o-xylene route in part because it is soluble! Other reactions with phthalic anhydride became drowsy, lost appetite and vomited reaction is to... Principal commercial form of phthalic anhydride is soluble in alcohol, and may produce asthma on repeated.... Thoroughly with plenty of water phthalic anhydride has also been used as monomer...