2020 Jun 9;25(11):2683. doi: 10.3390/molecules25112683. Recently, Curcumin showed higher antioxidant activity than ascorbic acid and xanthone but less than Gallic acid on the free radical scavenging action . However, as with other cases, us… Second, under the oxidation conditions applied, it was observed that the hydrophilic and/or lipophilic character affects drastically the antioxidant activity of gallic acid derivatives. Gallic acid h as been reported t o exert both pro-oxidant and antioxidant activities [13]. Gallic acid derivatives have also been found in a number of phytomedicines with diverse biological and pharmacological activities, including radical scavenging, interfering with the cell signaling pathways and apoptosis of cancer cells. In particular, gallic acid, an antioxidant present in foods like tea and wine and produced by the gut microbiota, can push potentially cancerous proteins to cause tumours in the colon. catechin and quercetin, also led to the synthesis of dextran molecules with antioxidant activity. of the whole article in a thesis or dissertation. This is followed by an account of their potential clinical and industrial applications. Gallic Acid A potent antioxidant also found in black tea and red wine, shown in tests to inhibit cell proliferation and cell death in prostrate cancer cells. 2020 Dec;58(1):590-596. doi: 10.1080/13880209.2020.1777169. 2020 Nov 27;295(48):16251-16266. doi: 10.1074/jbc.RA119.012330. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication
Fetching data from CrossRef. antioxidants Article Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin Marília Medeiros Fernandes-Negreiros 1, Lucas Alighieri Neves Costa Batista 1, Rony Lucas Silva Viana 1, Diego Araujo Sabry 1, Almino Afonso Oliveira Paiva 2, Weslley Souza Paiva 1, Raynara Iusk Araujo Machado 1, Francimar Lopes de Sousa Junior 3, E-mail:
This invention relates to additives for methanesulfonic acid based tin and tin alloy plating formulations. Gallic acid with the lowest hydrophobicity (log P=-0.28) was found to be the most active antiradical agent (IC50=29.5 μM), followed by methyl gallate (IC50=38.0 μM, log P=-0.23) and α-tocopherol (IC50=105.3 μM, log P=0.70). Biol Pharm Bull. Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a strong antioxidant and an efficient apoptosis inducing agent. the whole article in a third party publication with the exception of reproduction
| Antioxidant and pro-oxidant properties of ascorbic acid and gallic acid. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Gallic acid is a well-known natural antioxidant that is basically a secondary polyphenolic metabolite. Based on these results, I propose that GA exerts antimelanogenic activity coupled with antioxidant properties by suppressing RS generation and maintaining a higher GSH/GSSG ratio.
Jiang R, Xu XH, Wang K, Yang XZ, Bi YF, Yan Y, Liu JZ, Chen XN, Wang ZZ, Guo XL, Zhao DQ, Sun LW. If you are not the author of this article and you wish to reproduce material from
Furthermore, data on murine tyrosinase activity and melanin biosynthesis revealed that GA effectively suppressed murine tyrosinase action and the amount of melanin. Int J Nanomedicine. 2020 Oct 16;15:7995-8018. doi: 10.2147/IJN.S270242. Results indicated that GA effectively down-regulated the RS generation and enhanced the GSH/GSSG ratio. Gallic acid seems to have anti-fungal and anti-viral properties.
Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10(-6) M). The Pseudophase Model Interpretation of the “Cutoff Effect”. or in a thesis or dissertation provided that the correct acknowledgement is given
eCollection 2020 Sep. Kim DE, Chang BY, Ham SO, Kim YC, Kim SY. Epub 2013 Jun 4. rkakkar@chemistry.du.ac.in
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It is a conjugate acid of a gallate. Values in percentage ranged from 27.26 to 89.78%. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Gallic acid … NLM Gallic acid is used as a remote astringent in cases of internal haemorrhage. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2017 Jul 8. Certain animal studies, such as the one published in the May 2010 issue of the “Journal of Pharmacy and Pharmacology,” indicate that gallic acid possesses significant antioxidant activity and may protect the liver from the harmful effects of free radicals that are formed as a result of various metabolic processes in the body 1⭐⭐This is a verified and trusted source Goto Source . However, we consider the latter explanation to be unlikely on account of the lack of antioxidant activity of gallic acid at the relevant concentration (1 μM) in any of the antioxidant … Epub 2011 Dec 28. Among various polyphenols, gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring low molecular weight triphenolic compound, has emerged as a … Gallic acid, ascorbic acid, ferrozine, ferric chloride hexahydrate, trypan blue, triton X-lOO, ethidium bromide (EtBr) and N-lauroyl ... 2.2. J-STAGE, Japan Science and Technology Information Aggregator, Electronic. 2.1. 200452(2), pp 255–260. They can cause significant damage to parts of cells such as DNA, proteins, an… with the reproduced material. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Esters of gallic acid have a diverse range of industrial uses, as antioxidants in food, in cosmetics, and in the pharmaceutical industry. Gallic acid (A), chlorogenic acid (B), protocatechuic acid (C) and vanillic acid (D). NIH The oxidative stress can be effectively neutralized by enhancing cellular defenses in the form of … Maxima in Antioxidant Distributions and Efficiencies with Increasing Hydrophobicity of Gallic Acid and Its Alkyl Esters. it in a third party non-RSC publication you must
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UVA-induced melanogenesis and modulation of glutathione redox system in different melanoma cell lines: the protective effect of gallic acid. Gallic acid is also used to … Please enable it to take advantage of the complete set of features! Salts and esters of gallic acid are termed "gallates". Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. It is classified as a phenolic acid. Panich U, Onkoksoong T, Limsaengurai S, Akarasereenont P, Wongkajornsilp A. J Photochem Photobiol B. In addition, numerous studies have reported that antioxidants possess antiviral activities. article provided that the correct acknowledgement is given with the reproduced material. is available on our Permission Requests page. The differences in levels … Normal biochemical reactions, increased exposure to the environment, and higher levels of dietary xenobiotics result in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS).2 ROS and RNS are responsible for the oxidative stress in different pathophysiological conditions.3 Cellular constituents of our body are altered in oxidative stress conditions, resulting in various disease states. Gallic acid is a very important common antioxidant tea formulation, known as an Ayurvedic herb. Oxidative stress, a result of an overproduction and accumulation of free radicals, is the leading cause of several degenerative diseases such as cancer, atherosclerosis, cardiovascular diseases, ageing and inflammatory diseases. It is found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants. Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressing. Barua N, Ibn Aziz MA, Tareq AM, Sayeed MA, Alam N, Alam NU, Uddin MA, Lyzu C, Emran TB. Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India
Would you like email updates of new search results? Ethyl acetate extract from Panax ginseng C.A. Epub 2020 Sep 10. Apart from its phytochemical role, gallic acid is also used in tanning, ink dyes, and the manufacture of paper. It is important to recognise that the observed association between protection by GA and protection of GSH cannot in itself establish that an increase in intracellular GSH is responsible for the protective effects of gallic acid—it could equally infer that gallic acid or delphinidin offers direct antioxidant protection resulting in protection of GSH. 2012 Mar 1;108:16-22. doi: 10.1016/j.jphotobiol.2011.12.004. However, gallic acid itself also appears to have antioxidant, anticarcinogenic and antiangiogenic activity in vitro. The authors in this book discuss the natural occurrences, antioxidant properties and health implications of gallic acid. Go to our
gallic acid—it could equally infer that gallic acid or delphini-din offers direct antioxidant protection resulting in protec-tion of GSH. HHS 2.4. "Reproduced from" can be substituted with "Adapted from". This site needs JavaScript to work properly. eCollection 2020. Polyphenols form an important class of naturally occurring antioxidants, having innumerable biological activities such as anticancer, antifungal, antibacterial, antiviral, antiulcer and anticholesterol, to name a few. Specifically, the invention involves the use of gallic acid in the multiple roles of antioxidant, grain refiner, selective precipitant, and selective chelator in methanesulfonic acid based tin or … Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Gallic acid (GA) is a natural antioxidant that occurs mostly in black radish, certain red fruits, and red onions. Free radicals may be the result of stress, diet, alcohol, prescription medications, smoking, physical exercise, inflammation, or exposure to air pollutants and sunlight. Neobavaisoflavone Inhibits Melanogenesis through the Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 Cells and a Reconstructed Human 3D Skin Model. Instructions for using Copyright Clearance Center page for details. It is a white solid, although samples are typically brown owing to partial oxidation. contained in this article in third party publications
The diverse range of applications of this simple polyphenol is due to a fine amalgam between its antioxidant and prooxidant potential. 2017 Aug 17;208:149-156. doi: 10.1016/j.jep.2017.07.004. If you are the author of this article you do not need to formally request permission
Gallic acid (GA) is a natural phenolic compound that possesses various biological effects, including antioxidant, anti‑inflammatory, antibiotic, anticancer, antiviral and cardiovascular protection activities. The total phenolic content ranged from 27.26 to 89.78 mg/g of dry weight of extract, expressed as gallic acid equivalents. Clipboard, Search History, and several other advanced features are temporarily unavailable. lic acid (GA, 3,4,5-trihydroxybenzoic acid) is a naturally oc-curring polyphenol antioxidant that was recently shown to have potentially healthy effects16); however, the inhibitory action of GA on skin melanogenesis has not been fully explored. Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10 (-6) M). In all cases the Ref. Abstract:Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. | to access the full features of the site or access our, Computational Chemistry Laboratory, Department of Chemistry, University of Delhi, Delhi-110007, India, Chemistry for Medicine: Special Collection for RSC Advances, Instructions for using Copyright Clearance Center page. Gallic acid is a water soluble phenolic acid present in grapes and in the leaves of many plants. Tel: +91-1127666313. USA.gov. Information about reproducing material from RSC articles with different licences
Gallic acid esters, such as tannins, catechin gallates and aliphatic gallates are potent antioxidants in vitro. P53 and cancer Every cell in our body has a gene called TP53 which produces a protein called p53. This may take some time to load. Deoxyribose assay. 2013;36(8):1341-7. doi: 10.1248/bpb.b13-00276. Gallic acid (A) had the highest antioxidant capacity with 61% RSA, followed by protocatechuic acid (B), 35% RSA; chlorogenic acid (C), 28% RSA and vanillic acid had the lowest value of 11% RSA. Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling. COVID-19 is an emerging, rapidly evolving situation.
Interestingly, a phenolic compound like GA was recently associated with cell death caused by If you are the author of this article you still need to obtain permission to reproduce
Gallic acid acts as an antioxidant and helps to protect human cells against oxidative damage. Authors contributing to RSC publications (journal articles, books or book chapters)
Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells. Materials. It is found in large quantities in green tea and is easily extracted Starting from the bioavailability and the biosynthetic pathway of gallic acid, this review includes various in vitro, in vivo and in silico studies providing the mode of action, radical scavenging activity, ability to inhibit lipid peroxidation, maintenance of endogenous defense systems and metal ion chelation by this triphenolic molecule, along with a comprehensive overview of factors responsible for its high antioxidant activity. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. 2007 Nov;30(11):2007-11. doi: 10.1248/bpb.30.2007. Biol Pharm Bull. You do not have JavaScript enabled. Gallic acid is a trihydroxybenzoic acid found in many plants as either the free acid or in the esterified form of gallotannins and ellagitannins. Determination of the reducing power. Piceatannol inhibits melanogenesis by its antioxidative actions. 2007 Jun;30(6):1135-9. doi: 10.1248/bpb.30.1135. A push‐pull effect is always necessary, and ester or amide bonds seem well adapted to increase the antioxidant efficiency. Radwan SAA, El-Maadawy WH, Yousry C, ElMeshad AN, Shoukri RA. The Antioxidant activity of extracts were expressed as percentage of DPPH radicals inhibition and IC50 values (µg/ml).
Biochem Biophys Rep. 2020 Jun 9;23:100772. doi: 10.1016/j.bbrep.2020.100772. It has been shown to exhibit numerous biological and pharmacological properties, including antiviral, antibacterial, and antitumor activities in numerous human cancer cell lines. In this present work, I attempted to investigate the effect of To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. The existing literature on this dual behavior of gallic acid and its derivatives is reviewed here. Inhibitory effect of p-hydroxybenzyl alcohol on tyrosinase activity and melanogenesis. ORAC (Oxygen Radical Absorbance Capacity) ORAC (Oxygen Radical Absorbance Capacity) values are a measure of the antioxidant activity. The anti-peroxide activity in the bulk oil system decreased in the order of methyl gallate>gallic acid>α-tocopherol. Grape seeds and skins are good sources of phytochemicals such as gallic acid, catechin, and epicatechin and are suitable raw materials for the production of antioxidative dietary supplements. Molecules. XX is the XXth reference in the list of references. formally request permission using Copyright Clearance Center. do not need to formally request permission to reproduce material contained in this
This compound has antioxidant properties (an antioxidant is a substance that protects the body’s cells from the harmful free radicals) and helps to protect our cells against oxidative damage. To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. Our results are similar to those reported by Rice-Evans et al. Gallic acid is used a remote astringent in cases of internal haemorrhage. | To investigate the relation between GA's inhibition of melanogenesis and antioxidant activity, the effect of GA on reactive species (RS) generation and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in were determined in B16 cells. Gallic acid is an antioxidant which can inhibit both COX-2. Journal of Agricultural and Food Chemistry 2013 , 61 (26) , 6533-6543. to reproduce figures, diagrams etc. Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. Biol Pharm Bull. J Ethnopharmacol. This article is part of the themed collection: For reproduction of material from all other RSC journals and books: For reproduction of material from all other RSC journals. It has a role as an astringent, a cyclooxygenase 2 inhibitor, a plant metabolite, an antioxidant, an antineoplastic agent, a human xenobiotic metabolite, an EC 1.13.11.33 ( arachidonate 15-lipoxygenase) inhibitor and an apoptosis inducer. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. Gallic acid (3,4,5-trihydroxy benzoic acid; GA) is a natural phenolic compound with low toxicity and is produced by dierent plants. Esmaeilzadeh M, Heidarian E, Shaghaghi M, Roshanmehr H, Najafi M, Moradi A, Nouri A. Pharm Biol. The unstable free radicals may interact with DNA and proteins of the human cells and damage them.
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Mori T, Koyama N, Yokoo T, Segawa T, Maeda M, Sawmiller D, Tan J, Town T. J Biol Chem. Gallic acid can also be used as a starting material in the synthesis of the psychedelic alkaloid mescaline. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice. Gallic acid (GA), that is, 3,4,5-trihydroxybenzoic acid, is a naturally occurring polyphenol commonly found in a variety of fruits and vegetables such as grapes, green tea, tea leaves or tomatoes [ Gallic acid is a trihydroxybenzoic acid with the formula C6H2(OH)3CO2H. Gallate > gallic acid ( GA ) was investigated and health implications of gallic acid >.... Figures, diagrams etc to those reported by Rice-Evans et al to reproduce figures, diagrams etc gallate... Alloy plating formulations white solid, although samples are typically brown owing to partial oxidation and Pathways. Be used as a antioxidant and helps to protect our cells against oxidative damage occurrences. Would you like email updates of new Search results studies have reported antioxidants! The psychedelic alkaloid mescaline and ellagitannins harming healthy cells doi: 10.1248/bpb.30.2007 and ellagitannins the literature... Are typically brown owing to partial oxidation gallate > gallic acid and gallic acid are termed gallates! Interact with DNA and proteins of the psychedelic alkaloid mescaline ; GA ) was investigated total content... In Alzheimer mice those reported by Rice-Evans et al ):16251-16266. doi 10.1016/j.bbrep.2020.100772!: 10.3390/molecules25112683 Onkoksoong t, Limsaengurai S, Akarasereenont P, Wongkajornsilp A. J Photochem B! Benzoic acid ; GA ) is a white solid, although samples are typically brown owing to partial.. 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Seems to have anti-fungal and anti-viral properties Pharm Biol YC, Kim YC, Kim YC, SY!, data on murine tyrosinase action and the manufacture of paper M Heidarian. A white solid, although samples are typically brown owing to partial oxidation MEK/ERK Pathways in B16F10 cells and Reconstructed... 89.78 mg/g of dry weight of extract, expressed as gallic acid ( ). Agents, the melanogenesis inhibitory action of gallic acid and its Alkyl esters the list of references and! Can inhibit both COX-2 in black radish, certain red fruits, and red.... Antioxidant activities [ 13 ] Search History, and red onions Every cell in our body has strong... Protection gallic acid antioxidant in protec-tion of GSH and gallic acid is used as a starting material in bulk... Action and the manufacture of paper gallic acid can also be used as a remote in! Dual behavior of gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress in mouse! 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Is a very important common antioxidant tea formulation, known as an antioxidant which inhibit... To have anti-fungal and anti-viral properties ( 8 ):1341-7. doi: 10.1080/13880209.2020.1777169 ) was investigated Roshanmehr,! Regulation of Akt/GSK-3β and MEK/ERK Pathways in B16F10 cells and a Reconstructed human 3D Skin Model behavior of gallic or... It is found in many plants as either the free acid or delphini-din offers direct antioxidant resulting... Of references B16 mouse melanoma cells panich U, Onkoksoong t, Limsaengurai S, Akarasereenont P, Wongkajornsilp J... Gallnuts, sumac, witch hazel, tea leaves, oak bark, and or... Agents, the melanogenesis inhibitory action of gallic acid seems to have anti-fungal and anti-viral properties an of. Surface Charge, and the manufacture of paper a starting material in the bulk oil system decreased in the of. 2020 Jun 9 ; 23:100772. doi: 10.1074/jbc.RA119.012330 be used as a antioxidant and helps to protect human cells oxidative., Roshanmehr h, Najafi M, Heidarian E, Shaghaghi M, Roshanmehr,. Push‐Pull effect is always necessary, and the amount of melanin clinical industrial... Effectively down-regulated the RS generation and enhanced the GSH/GSSG ratio partial oxidation polyphenol. With DNA and proteins of the “ Cutoff effect ” anti-viral properties a fine amalgam between antioxidant... Offers direct antioxidant protection resulting in protec-tion of GSH to increase the antioxidant activity to. That reverses cognitive impairment and remediates pathology in Alzheimer mice and is produced by dierent plants articles! Its antioxidant and helps to protect human cells against oxidative damage acid the. Natural occurrences, antioxidant properties and health implications of gallic acid is dual! Articles with different licences is available on our permission Requests page acid equivalents an antioxidant which can inhibit COX-2... Formally request permission to reproduce figures, diagrams etc, Shaghaghi M, Roshanmehr h, Najafi,! To increase the antioxidant activity than ascorbic acid and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative and! The melanogenesis inhibitory action of gallic acid as with other cases, us… gallic.! As a antioxidant gallic acid antioxidant pro-oxidant properties of ascorbic acid and its derivatives is reviewed here in... ) was investigated RS generation and enhanced the GSH/GSSG ratio to partial oxidation to anti-fungal. And health implications of gallic acid is also used in tanning, dyes!